Preparation of Tritium Labeled Dexamethasone Phosphate and Its Application to Assess the Affinity of Ligands for Glucocorticoid Receptors

Abstract: The possibility of introducing tritium into dexamethasone and dexamethasone phosphate using the thermal activation method was demonstrated. The affinity of ligands for glucocorticoid receptors has been successfully assessed using labeled compounds. © Pleiades Publishing, Ltd. 2024.

Авторы
Badun G.A. , Zhidkova E.M. , Chernysheva M.G. , Enikeev A.D. , Yakubovskaya M.G. , Lesovaya E.A.
Journal
Radiochemistry
Номер выпуска
4
Язык
English
Страницы
514-521
Статус
Published
Ссылка
Внешняя ссылка
DOI
10.1134/S1066362224040131
Том
66
Год
2024
Организации
  • 1 Faculty of Chemistry, Moscow State University, Moscow, 119991, Russian Federation
  • 2 Blokhin Russian Cancer Research Center, Ministry of Health of Russia, Kashirskoe shosse 24, Moscow, 115478, Russian Federation
  • 3 Friendship University of Russia, ul. Miklukho-Maklaya 6, Moscow, 117198, Russian Federation
  • 4 Pavlov Ryazan State Medical University, Ministry of Health of Russia, Vysokovol’tnaya ul. 9, Ryazan, 390026, Russian Federation
Ключевые слова
glucocorticoid; glucocorticoid receptor; radioligand binding assay; selective glucocorticoid receptor agonists; tritium
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