Oral and maxillofacial prosthodontics is engaged in prosthetics of congenital and acquired defects of the maxillofacial region occurred from resections of the jaws in case of neoplasms and as a result of injuries as well. In the presence of defects in the maxillofacial region, various methods of treatment are currently used, including removable prosthetics, reconstruction of the defect with a vascularized musculoskeletal autograft, and prosthetics with implants. This direction tends to be further developed and improved, which will contribute to the full integration of the patient into society. In this article the method of prosthetic treatment of the defect occurring at maxillary resection (clinical case) followed by prosthetic rehabilitation is presented. © 2023, Akra LLC. All rights reserved.