Early non-invasive rapid diagnostics of the head and neck skin basal cell carcinoma for improving the quality of cancer care organization

Current Healthcare service needs to develop the methods of early detection of socially significant diseases, including to improve the quality of cancer care organization, as patients with malignant neoplasms visit a doctor lately, when the treatment may be not ef-fective. Accordingly, attention should be paid to methods of prevention and early non-invasive diagnostics of this pathology. The use of optical technologies seems promising for this purpose. The article presents an experimental substantiation of using technology of confocal photoluminescence microspectroscopy and Raman scattering at a wavelength of 532 nm in vitro as the first stage of early non-invasive diagnostics method’s development of skin cancers, in this case — head and neck cutaneous basal cell carcinoma (BCC). The study analyzed the spectrum of intact skin tissue and BCC, which was accompanied with morphological confirmation of the diagnosis. The examination of intact skin tissue, using scanning Raman confocal Confotec MR520 («SOL In-struments», the Republic of Belarus) microscope-spectrometer, photoluminescence effects and Raman scattering. The experimental substantiation for development of optical diagnostic parameters’ set, which allows to analyze the changes occurring in different layers of human skin in normal and in case of skin BCC in real time, was carried out. The obtained results can serve as a pre-paratory stage to develop an early non-invasive diagnostics method of various types of skin neoplasms in short period to identify a malignant process at the initial stage and to improve cancer care. © 2023, Media Sphera Publishing Group. All rights reserved.