Peculiarities of the Application of Mathematical Models Describing Mass-Transfer Processes in Film Coating Technology for a Biconvex Tablet

A review concerning peculiarities of the application of mathematical models describing mass-transfer processes in film coating technology is presented. A formula to calculate the coating film thickness for a biconvex tablet is given. A model based on the Fokker–Planck equation is described. It determines the law of distribution of coated tablets by weight and allows equations for calculating the average weight and dispersion of a coated tablet to be obtained. Therefore, the uniformity of the distribution of the coating material over the tablets can be evaluated. The mass-transfer equations shown in the review make it possible to calculate characteristics such as the product moisture content and the humidity in a coater drum. © 2022, Springer Science+Business Media, LLC, part of Springer Nature.

Authors
Tishkov S.V. , Gavrilov D.I. , Blynskaya E.V. , Alekseev K.V. , Bueva V.V. , Vinogradov V.P.
Number of issue
4
Language
English
Pages
503-508
Status
Published
Volume
56
Year
2022
Organizations
  • 1 Zakusov Research Institute of Pharmacology, 8 Baltiiskaya St, Moscow, 125315, Russian Federation
  • 2 People’s Friendship University of Russia, 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation
Keywords
coating uniformity; film coatings; mass-transfer processes; mathematical modeling; solid dosage forms
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