Anesthesia risk is common in dental practice. This article presents the dynamic assessment of various patient-related parameters during dental implant surgery under local anesthesia in combination with oxygen-xenon inhalation. The following was noted in the studied group of patients in comparison with the control group: 1) decreased intensity of pain sensations according to the HADS scale during and after surgery; 2) increased blood saturation; 3) slight increase in systolic and diastolic BP with subsequent return to baseline values; 4) decreased HR; 5) significant decrease in Kerdo index, with a subsequent gradual increase within the range below the initial values; 6) decreased dose of local anesthetic required for optimal anesthesia. Based on the above, conclusions were made about a pronounced and prolonged psychotropic, autotropic, and neurotropic effect when using local anesthesia in combination with inhalation of oxygen-xenon mixture. © Team of authors, 2022.