Benign-by-design sustainable protocol for the synthesis of furosemide

This study discloses a benign-by-design synthetic protocol for furosemide using a biomass-derived active pharmaceutical ingredient. The optimized protocol, designed for efficiency, was implemented within an hour using a microwave reactor and a range of environmentally friendly solvents. Investigations were carried out to assess the influence of additives and reaction media on the synthesis process. Green metrics were measured to propose an environmentally sound protocol aiming to minimize waste generation. These findings advance the development of a sustainable and efficient synthesis route for furosemide. © 2024

Authors
Minio F. , Torriente A.H. , Balu A.M. , Vaccaro L. , Osman S.M. , Luque R. 4 , Chhabra T.
Journal
Sustainable Chemistry and Pharmacy
Publisher
Elsevier Science Publishing Company, Inc.
Language
English
Status
Published
Link
External link
DOI
10.1016/J.SCP.2024.101600
Number
101600
Volume
39
Year
2024
Organizations
  • 1 Dipartimento di Chimica, Biologia e Biotecnologie, Università Degli Studi di Perugia, Via Elce di Sotto 8, Perugia, 06123, Italy
  • 2 Departamento de Quimica Organica, Universidad de Cordoba, Ctra Nnal IV-A, Km 396, Cordoba, E14014, Spain
  • 3 Chemistry Department, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia
  • 4 Peoples Friendship University of Russia (RUDN University), 6 Miklukho Maklaya str., Moscow, 117198, Russian Federation
  • 5 Universidad, ECOTEC, Km 13.5 Samborondón, Samborondón, EC092302, Ecuador
Keywords
Active pharmaceutical ingredients; Biomass; Furan derivatives; Furosemide; Microwave irradiation
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