New pyridine dithiaazacrown ether derivatives: synthesis, structural characterization, in silico and in vitro biological studies

New derivatives of dithiaazacrown ethers containing ψ-arylpyridine subunits were prepared based on the Hantzsch synthesis. The obtained compounds showed potential activities toward Hep-G2 cancer cell line, in both in silico and in vitro studies. The compounds were also good ligands for complex chemistry with metal ions due to possessing up to four heteroatoms and relatively big size of the crown ring. © 2024

Authors
Tran V.T.T. , Dao N.T. , Do T.T. , Pham T.T.T. , Le D.T. , Khrustalev V.N. , Nguyen P.T.T. , Le A.T.
Journal
Mendeleev Communications
Publisher
Royal Society of Chemistry
Number of issue
4
Language
English
Pages
514-517
Status
Published
Link
External link
DOI
10.1016/J.MENCOM.2024.06.014
Volume
34
Year
2024
Organizations
  • 1 Faculty of Chemistry, University of Science, Vietnam National University, Hanoi, Hanoi, 100000, Viet Nam
  • 2 Thai Nguyen University of Medicine and Pharmacy, Thai Nguyen, Thai Nguyen City, 250000, Viet Nam
  • 3 Peoples’ Friendship University of Russia (RUDN University), Moscow, 117198, Russian Federation
  • 4 N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, 119991, Russian Federation
  • 5 FPT University, Fschool Hoa Lac, Hanoi, Viet Nam
Keywords
arylpyridine subunit; crown ring; dithiaazacrown ethers; Hantzsch synthesis; Hep-G2
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