Investigations into the impact of non-coding RNA on the sensitivity of gastric cancer to radiotherapy

Non-coding RNAs (ncRNAs) are a newly discovered functional RNA different from messenger RNA, which can participate in regulating the occurrence and development of tumors. More and more research results show that ncRNAs can participate in the regulation of gastric cancer (GC) radiotherapy response, and its mechanism may be related to its effect on DNA damage repair, gastric cancer cell stemness, cell apoptosis, activation of epidermal growth factor receptor signaling pathway, etc. This article summarizes the relevant mechanisms of ncRNAs regulating the response to radiotherapy in gastric cancer, which will be directly important for the introduction of ncRNAs particularly microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) into clinical medicine as biomarkers and therapeutic targets. Copyright © 2023 Usman, Beilerli, Sufianov, Kudryashov, Ilyasova, Balaev, Danilov, Lu and Gareev.

Authors
Usman M. , Beilerli A. , Sufianov A. , Kudryashov V. , Ilyasova T. , Balaev P. , Danilov A. , Lu H. , Gareev I.
Language
English
Status
Published
Number
1149821
Volume
14
Year
2023
Organizations
  • 1 Department of Medical Imaging, Central Hospital Affiliated to Chongqing University of Technology, Chongqing, China
  • 2 Department of Obstetrics and Gynecology, Tyumen State Medical University, Tyumen, Russian Federation
  • 3 Department of Neurosurgery, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
  • 4 Department of Internal Diseases, Bashkir State Medical University, Ufa, Russian Federation
  • 5 Gastric Cancer Center, West China Hospital of Sichuan University, Sichuan, Chengdu, China
  • 6 Department of Oncology and Radiology, Ural State Medical University, Yekaterinburg, Russian Federation
  • 7 Department of Clinical Pharmacology, Smolensk State Medical University, Smolensk, Russian Federation
  • 8 Educational and Scientific Institute of Neurosurgery, Рeoples’ Friendship University of Russia (RUDN University), Moscow, Russian Federation
Keywords
biofluids; biomarkers; gastric cancer; non-coding RNA; oncogenesis; radiotherapy; therapeutic targets

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