The purpose of the work is to determine the role of Big Data in the development of the information society and the digital economy during the transition to Industry 4.0. Using the regression analysis method, the impact of Big Data and analytics on the information society is determined—agility of companies, e-participation and e-government based on IMD statistics. A sample of 10 developed and developing countries leading in the field of digital economy in 2021 was formed for the study. As a result, it is proved that Big Data can and already now play an important system-forming role in the integrated development of the information society and the digital economy, contributing to the transition to Industry 5.0. The theoretical significance of this conclusion is that it has expanded the range of applications of Big Data, as well as filled a gap in the technological support of the transition to industry 5.0, supplementing artificial intelligence with Big Data. The practical significance of the obtained results lies in the fact that they opened up the possibility of a practical transition to Industry 5.0 based on the use of Big Data, thereby supporting and accelerating the Fifth Industrial Revolution. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.