Photoredox-Catalyzed Chlorotrifluoromethylation of Arylallenes: Synthesis of a Trifluoromethyl Building Block

A new class of trifluoromethyl building blocks─2-trifluoromethyl allyl chlorides─have been obtained through a photoredox-catalyzed chlorotrifluoromethylation of aryl allenes. The reaction proceeded in a regio- and stereoselective manner. A trifluoromethylated analog of the flunarizine drug was synthesized. © 2023 American Chemical Society.

Authors
Storozhenko O.A. , Festa A.A. , Zolotareva V.A. , Rybakov V.B. , Varlamov A.V. , Voskressensky L.G.
Journal
Number of issue
2
Language
English
Pages
438-442
Status
Published
Volume
25
Year
2023
Organizations
  • 1 Organic Chemistry Department, Science Faculty, Peoples’ Friendship University of Russia (RUDN University), Miklukho-Maklaya Street 6, Moscow, 117198, Russian Federation
  • 2 Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory 1-3, Moscow, 119991, Russian Federation
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