Construction site layout planning (CSLP) is the process of allocating temporary facilities needed on construction site. It is a complex process that aims at minimizing travel distances while improving productivity and safety. Although previous studies have enhanced the CSLP, there is a lack of studies that benefit from the potential of Building Information Modelling (BIM)-Generative Design (GD) integration in the field of site layout planning. This study aims to understand the CSLP problem from new aspects to facilitate its use for construction practitioners and site planners. The research presents a new modelling and optimization concept that utilizes BIM-GD tool to target optimum construction site layout plans to ensure a safe and productive work environment. The developed model applies the parametric visual programming basics (VP) to build the layout problem for optimization. The research includes a case study from the literature to demonstrate the applicability of the proposed model. The results show a high validity for the model compared with previous models in terms of defining the problem from new aspects and applying all the calculations within the BIM environment software. The presented study shows great potential from the GD tool for more practical and complex applications in future research.