Влияние перинатального воздействия алкоголя на концентрацию витаминов в крови детей

Проведен анализ концентрации водорастворимых и жирорастворимых витаминов в крови беременных женщин, злоупотребляющих алкоголем, а также их детей с целью оценки роли нарушения метаболизма витаминов в развитии фетального алкогольного синдрома. Выдвинуто предположение о важности мониторинга витаминного профиля, в первую очередь, витаминов С и Е у детей, подвергшихся перинатальному воздействию алкоголя, в качестве необходимого инструмента раннего выявления этанол-индуцированных нарушений.

The effect of perinatal exposure of alcohol on the concentration of vitamins in blood of children

Violation of the metabolism of vitamins can play a significant role in the development of FAS. In this regard, the purpose of this study was to analyze the concentration of water-soluble and fat-soluble vitamins in the blood of pregnant women who abuse alcohol, as well as their children. Thirty pregnant women (3 terms) were examined, of which 15 suffered from chronic alcoholism, and their children (30). Determination of the concentration of isolated vitamins was carried out by high-performance liquid chromatography on a PerkinElmer S200 instrument. Perinatal exposure to ethanol is associated with a decrease in the concentration of vitamins E and C in children's blood by 46% ( p = 0.001) and 23% ( p = 0.032), respectively. Despite the lack of significant group differences among women, the level of vitamin C in the blood of children significantly correlates with the level of ascorbic acid in the mother's body during the third trimester of pregnancy ( r = 0.379, p = 0.039). Regression analysis showed that the level of vitamins K and C in the blood of pregnant women is reliably associated with the Apgar score, whereas the concentration of vitamins C and B12 in children's blood is reliably correlated with the body weight at the age of 1 year. Given the relationship between the supply of vitamin C and the development of the body, it is assumed that monitoring of the vitamin profile, especially of vitamins C and E, in children exposed to perinatal alcohol exposure is an essential tool for early detection of ethanol-induced disorders. Moreover, the timely use of vitamins C and E can prevent at least some of the metabolic disorders associated with perinatal exposure to ethanol, but this assumption requires further investigation.