Изменения липидного обмена и свободнорадикального окисления при экспериментальной неалкогольной жировой болезни печени

Изучено состояние липидного обмена и свободнорадикального окисления (СРО) в сыворотке крови и ткани печени при диетиндуцированной неалкогольной жировой болезни печени (НЖБП) у крыс Wistar. Показано, что в процессе формирования гистологически подтвержденной НЖБП у животных развивается атерогенная дислипидэмия на фоне отсутствия индукции СРО в сыворотке крови при наличии снижения общих тиоловых соединений в печени.

Lipid profile and free radical oxidation in non-alcoholic fatty liver disease

Diet-induced liver steatosis is associated with metabolic syndrome, insulin resistance and cardiometabolic disorders such as abnormal lipoproteins metabolism, excessive accumulation of lipids in hepatocites and activation of free radicals formation. Consequently, the aim of the present study was to assess lipid spectrum and oxidative stress markers in rats with diet-induced non-alcoholic fatty liver disease (NAFLD). The animals were divided into two equal groups and fed standard diet (10% calories from fat) or high-calorie diet (HCD) (60% calories from fat in chow and 10% sucrose solution) for 6 weeks. Serum of blood and liver samples used for estimation of lipid spectrum and some markers of protein modification and lipids peroxidation. The obtained data showed that histologically verified NAFLD led to atherogenic dyslipidemia in rats, absence of free radical oxidation in serum, and a significant decrease in total thiols concentration in liver. This fact may indicate the formation of local oxidative stress in liver of rats fed high-calorie diet.