ФАГОЦИТИРОВАНИЕ ПОЛИМЕРНЫХ МИКРОСФЕР, ИММОБИЛИЗОВАННЫХ БИОЛИГАНДАМИ, ЛЕЙКОЦИТАМИ ПЕРИФЕРИЧЕСКОЙ КРОВИ У БОЛЬНЫХ С ОСТРЫМ ПАНКРЕАТИТОМ

PHAGOCYTOSIS OF POLYMER MICROSPHERES IMMOBI­LIZED BY BIOLIGANDS LEUKOCYTES OF THE PERIPH­ERAL BLOOD IN PATIENTS WITH ACUTE PANCREATI­TIS

Phagocytosis of polymer microspheres both modified and un­modified by bioligands (gelatin, fibronectin and A protein) by leu­kocytic blood cells of patients with acute pancreatitis. The presence of bioligands in the surface of polymer microspheres and their ac­tivity were monitored by the reaction of latex agglutination with an appropriate ligand being involved. The study resulted in designing a method of phagocytosis implementation that can be used to evalu­ate the content of certain receptors in cellular membranes and, sub­sequently, to define the changed receptor cell apparatus caused by a disease. The nature of polymer microspheric bioligands immobilized to the surface was shown to influence significantly the activity of leukocytic blood cells.