Genetic counseling for prostate cancer risk

Nieder AM, Taneja SS, Zeegers MPA and Ostrer H. Genetic counseling for prostate cancer risk.

Clin Genet 2003: 63 169-176. © Blackwell Munksgaard, 2003

Major risk factors for developing prostate cancer, including positive family history and African-American ethnicity, can be quantified for genetic counseling. Factors increasing familial risk for prostate cancer are closer degree of kinship, number of affected relatives, and early age of onset (< 50 years) among the affected relatives. Genetic testing may be useful for modification of risk, but currently should be performed only within the context of a well-designed research study that will determine penetrance and genotype-phenotype correlation of specific mutations. Even in the absence of genetic testing, African-American men and men with a strong family history of prostate cancer may opt to initiate screening by prostate specific antigen (PSA) and digital rectal exam (DRE) screening at age 40.

Authors
Nieder AM 1 , Taneja SS , Zeegers MPA2 , Ostrer H.
Publisher
Munksgaard International Publishers
Number of issue
3
Language
English
Pages
169-176
Status
Published
Volume
63
Year
2003
Organizations
  • 1 Department of Urology
  • 2 Department of Epidemiology, Maastricht University, Maastricht, the Netherlands
Keywords
prostate cancer-genetic counseling-genetic testing-risk assessment
Date of creation
08.07.2024
Date of change
08.07.2024
Short link
https://repository.rudn.ru/en/records/article/record/113577/
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