Pharmacokinetic Properties of 99mTc-PSMA: A New Radiopharmaceutical for SPECT Imaging of Prostate Cancer

Prostate-specific membrane antigen (PSMA), which is overexpressed in advanced prostate cancer, is a well-established target for the development of antitumor diagnostic and therapeutic radiopharmaceuticals. The aim of this work is the preclinical study of the pharmacokinetics of a new radiopharmaceutical 99mTc-PSMA. Tumor uptake of 99mTc-PSMA is 1.81–3.91%/g with a maximum uptake of 3.91 ± 0.35%/g at 3 h of post-injection. The highest uptake (up to 140.11%/g) of 99mTc-PSMA throughout the study was observed in the kidneys. Tumor uptake of 99mTc-PSMA was higher than in other organs and tissues, except the kidneys

Authors
Tishchenko V.K.1 , Vlasova O.P. 1, 2 , Ivannikov A.I. 1 , Dorovatovskiy S.A.1, 3 , Pankratov A.A. 4 , Morozova N.B.4 , Fedorova A.V.1 , Lebedeva A.A.1 , Kuzenkova K.A.1 , Stepchenkova E.D.1 , Khailov A.M.1 , Shegai P.V. 1, 2 , Ivanov S.A. 1, 5 , Kaprin A.D. 2, 4, 5
Number of issue
11
Language
English
Pages
2513-2518
Status
Published
Volume
86
Year
2023
Organizations
  • 1 Tsyb Medical Radiological Research Center, Branch of the National Medical Research Radiological Center, Ministry of Health of the Russian Federation
  • 2 National Medical Research Radiological Center, Ministry of Health of the Russian Federation
  • 3 Limited liability corporation MEDICARE
  • 4 Moscow Oncology Research Institute, Branch of the National Medical Research Radiological Center, Ministry of Health of the Russian Federation
  • 5 Рeoples’ Friendship University of Russia (RUDN University)
Keywords
prostate-specific membrane antigen (PSMA); technetium-99m; prostate cancer; radionuclide diagnostics; pharmacokinetics; Particle and nuclear physics
Date of creation
01.07.2024
Date of change
01.07.2024
Short link
https://repository.rudn.ru/en/records/article/record/110761/
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