СБОРНИК ПРОЕКТОВ КОНКУРСА "ВСЕРОССИЙСКАЯ НАУЧНАЯ ШКОЛА "МЕДИЦИНА МОЛОДАЯ".
2023.
P. 1124-1126
Pharmacokinetic Properties of 99mTc-PSMA: A New Radiopharmaceutical for SPECT Imaging of Prostate Cancer
Prostate-specific membrane antigen (PSMA), which is overexpressed in advanced prostate cancer, is a well-established target for the development of antitumor diagnostic and therapeutic radiopharmaceuticals. The aim of this work is the preclinical study of the pharmacokinetics of a new radiopharmaceutical 99mTc-PSMA. Tumor uptake of 99mTc-PSMA is 1.81–3.91%/g with a maximum uptake of 3.91 ± 0.35%/g at 3 h of post-injection. The highest uptake (up to 140.11%/g) of 99mTc-PSMA throughout the study was observed in the kidneys. Tumor uptake of 99mTc-PSMA was higher than in other organs and tissues, except the kidneys
Authors
Tishchenko V.K.1
,
Vlasova O.P.
1,
2
,
Ivannikov A.I.
1
,
Dorovatovskiy S.A.1,
3
,
Pankratov A.A.
4
,
Morozova N.B.4
,
Fedorova A.V.1
,
Lebedeva A.A.1
,
Kuzenkova K.A.1
,
Stepchenkova E.D.1
,
Khailov A.M.1
,
Shegai P.V.
1,
2
,
Ivanov S.A.
1,
5
,
Kaprin A.D.
2,
4,
5
Journal
Number of issue
11
Language
English
Pages
2513-2518
Status
Published
Volume
86
Year
2023
Organizations
- 1 Tsyb Medical Radiological Research Center, Branch of the National Medical Research Radiological Center, Ministry of Health of the Russian Federation
- 2 National Medical Research Radiological Center, Ministry of Health of the Russian Federation
- 3 Limited liability corporation MEDICARE
- 4 Moscow Oncology Research Institute, Branch of the National Medical Research Radiological Center, Ministry of Health of the Russian Federation
- 5 Рeoples’ Friendship University of Russia (RUDN University)
Keywords
prostate-specific membrane antigen (PSMA); technetium-99m; prostate cancer; radionuclide diagnostics; pharmacokinetics; Particle and nuclear physics
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