Structure and Neuroprotector Properties of a Complex Compound of Lithium with Comenic Acid

The structure, antioxidant and neuroprotective properties of lithium comenate (lithium 5-hydroxy-4-oxo-4H-pyran-2-carboxylate) were studied. Lithium comenate was obtained by reacting comenic acid (H2Com) with lithium hydroxide in an aqueous solution. The structure of lithium comenate was confirmed via thermal analysis, mass spectrometry, IR, NMR and UV spectroscopy. The crystal structure was studied in detail via X-ray diffraction. The compound crystallized in a non-centrosymmetric space group of symmetry of the orthorhombic system Pna21 in the form of a hydrate, with three water molecules entering the first coordination sphere of the cation Li+ and one molecule forming a second environment through non-valent contacts. The gross formula of the complex compound was established [Li(HCom)(H2O)3]·H2O. It has been established that lithium comenate has a pronounced neuroprotective activity under the excitotoxic effect of glutamate, increasing the survival rate of cultured rat cerebellar neurons more than two-fold. It has also been found that the pre-stress use of lithium comenate at doses of 1 and 2 mg/kg has an antioxidant effect, which is manifested in a decrease in oxidative damage to the brain tissues of mice subjected to immobilization stress. Based on the data available in the literature, we believe that the high neuroprotective and antioxidant efficacy of lithium comenate is a consequence of the mutual potentiation of the pharmacological effects of lithium and comenic acid.

Authors
Kozin Stanislav1, 2, 3 , Kravtsov Alexandr1, 2 , Ivashchenko Lev4 , Dotsenko Victor4, 5 , Dzhimak Stepan1, 2 , Aksenov Nicolai5 , Vashurin Arthur6 , Ivlev Vasily 7 , Baryshev Mikhail2 , Bespalov Alexandr4 , Fedulova Lilia8 , Dorohova Anna1, 2 , Anashkina Anastasia9
Publisher
MDPI AG
Number of issue
1
Language
English
Pages
286
Status
Published
Volume
25
Year
2023
Organizations
  • 1 Physics and Technology Faculty, Kuban State University, 350040 Krasnodar, Russia
  • 2 Laboratory of Problems of Stable Isotope Spreading in Living Systems, Federal Research Center the Southern Scientific Center of the Russian Academy of Sciences, 344006 Rostov-on-Don, Russia
  • 3 Laboratory of Technologies for the Production of Physiologically Active Substances, Kuban State Technological University, 350072 Krasnodar, Russia
  • 4 Faculty of Chemistry and High Technologies, Kuban State University, 350040 Krasnodar, Russia
  • 5 Faculty of Chemistry and Pharmacy, North Caucasus Federal University, 355017 Stavropol, Russia
  • 6 Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences, 119071 Moscow, Russia
  • 7 Research and Educational Resource Center “Pharmacy”, RUDN University, 117198 Moscow, Russia
  • 8 Experimental Clinic-Laboratory of Biologically Active Substances of Animal Origin, The V.M. Gorbatov Federal Research Center for Food Systems of Russian Academy of Sciences, 109316 Moscow, Russia
  • 9 Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia
Keywords
gamma-pyrones; comenic acid; lithium; lithium comenate; lithium complex compounds; neuroprotection; antioxidant; excitotoxicity
Date of creation
17.05.2024
Date of change
20.05.2024
Short link
https://repository.rudn.ru/en/records/article/record/106966/
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