Synthesis and Preclinical Evaluation of Urea-Based Prostate-Specific Membrane Antigen-Targeted Conjugates Labeled with ¹⁷⁷Lu

Machulkin Aleksei E. ^{1, 2} , Petrov Stanislav A.¹ , Bodenko Vitalina^{3, 4} , Larkina Mariia S.^{3, 5} , Plotnikov Evgenii^{3, 6} , Yuldasheva Feruza³ , Tretyakova Maria³ , Bezverkhniaia Ekaterina^{3, 7} , Zyk Nikolay Yu.¹ , Stasyuk Elena⁸ , Zelchan Roman³ , Majouga Alexander G.⁹ , Tolmachev Vladimir¹⁰ , Orlova Anna⁷ , Beloglazkina Elena K.¹ , Yusubov Mekhman S.³

ACS Pharmacology & Translational Science

American Chemical Society

5

English

1457-1473

Published

External link

10.1021/acsptsci.4c00070

7

2024

• ¹ Department of Chemistry, M.V. Lomonosov Moscow State University, Leninskie Gory 1-3, Moscow 119991, Russian Federation
• ² Department for Biochemistry, People’s Friendship University of Russia Named after Patrice Lumumba (RUDN University), Moscow 117198, Russia
• ³ Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, Tomsk 634050, Russia
• ⁴ Scientific and Educational Laboratory of Chemical and Pharmaceutical Research, Siberian State Medical University, Tomsk 634050, Russia
• ⁵ Department of Pharmaceutical Analysis, Siberian State Medical University, Tomsk 634050, Russia
• ⁶ Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk 634014, Russia
• ⁷ Department of Medicinal Chemistry, Uppsala University, Uppsala 75183, Sweden
• ⁸ School of Nuclear Science and Engineering, Tomsk Polytechnic University, Tomsk 634050, Russia
• ⁹ Dmitry Mendeleev University of Chemical Technology of Russia, Miusskaya sq. 9, Moscow 125047, Russian Federation
• ¹⁰ Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala 75185, Sweden

14.05.2024

14.05.2024

https://repository.rudn.ru/en/records/article/record/106956/