Experimental study of myocardial collagen during nifedipine therapy of arterial hypertension

Light and electron microscopy of the left-ventricular myocardium obtained from spontaneously hypertensive SHR rats showed a pronounced increase in collagen content. These changes were more pronounced in animals treated with nifedipine in the mean therapeutic dose for 8 weeks. Collagen accumulated between muscle fibers and often formed perivascular cuffs. Hence, nifedipine promotes the formation of scleroproteins in the myocardium.

Authors
Publisher
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Number of issue
1
Language
English
Pages
16-18
Status
Published
Volume
135
Year
2003
Organizations
  • 1 Dept. of Pathological Physiology, Russian Univ. of Peoples' Friendship, Moscow, Russian Federation
Keywords
Arterial hypertension; Collagen; Myocardium; Nifedipine
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/100/
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