β-Amyloid: Alzheimer's Disease and Brain β-Amyloidoses

This review considers some aspects of the biochemistry of β-amyloid, a protein which produces insoluble deposits in the brain. These deposits are a specific morphological feature of Alzheimer's disease, Down's syndrome, and senile dementia. Our contribution to the concept of a soluble form of β-amyloid as of a normal human protein is presented.