We study the stability of static, spherically symmetric solutions to the Einstein equations with a scalar field as the source. We describe a general methodology of studying small radial perturbations of scalar-vacuum configurations with arbitrary potentials V(φ) and in particular space-times with throats (including wormholes), which are possible if the scalar is phantom. At such a throat, the effective potential for perturbations V<inf>eff</inf> has a positive pole (a potential wall) that prevents a complete perturbation analysis. We show that, generically, (i) V<inf>eff</inf> has precisely the form required for regularization by the known S-deformation method, and (ii) a solution with the regularized potential leads to regular scalar field and metric perturbations of the initial configuration. The well-known conformal mappings make these results also applicable to scalar-tensor and f(R) theories of gravity. As a particular example, we prove the instability of all static solutions with both normal and phantom scalars and V(φ) ≡ 0 under spherical perturbations. We thus confirm the previous results on the unstable nature of anti-Fisher wormholes and Fisher’s singular solution and prove the instability of other branches of these solutions including the anti-Fisher “cold black holes.”. © Springer-Verlag / Società Italiana di Fisica 2011.