DIAGNOSIS OF GENETIC FORMS OF AZOOSPERMIA

AIM: To identify the main genetic causes of azoospermia. METHODS. The study included 92 patients with azoospermia. In all patients we carried out genetic tests - karyotyping, PCR-diagnosis of blood. RESULTS. Genetic disorders were found in 35 (38%) men. Of these, the majority of men were with Kleinfelter syndrome - 21 (60%) and deletions in the AZF regions of the Y chromosome - 11 (31.4%). CONCLUSIONS. Patients who have genetic abnormalities should receive comprehensive medical and genetic advice.

Authors
Sturov N. 1 , Myandina G. 1 , Tarasova T. 2 , Saushev I. 2 , Pashina N. 3 , Korovyakova E. 1 , Barkhudarov A. 1 , Strachuk A. 1 , Karaseva N. 1 , Druzhinina N. 1 , Pashin S. 3
Journal
Archiv Euromedica
Publisher
European Scientific Society
Issue number
2
Language
English
Pages
111-113
State
Published
DOI
10.35630/2199-885X/2019/9/2/111
Volume
9
Year
2019
Organizations
  • 1 RUDN Univ, Peoples Friendship Univ Russia, Moscow, Russia
  • 2 Natl Res Ogarev Mordovia State Univ, Saransk, Russia
  • 3 IM Sechenov First Moscow State Med Univ, Moscow, Russia
Keywords
Male infertility; azoospermia; chromosomal abnormalities; Kleinfelter syndrome; AZF microdeletions
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