International Journal on Minority and Group Rights. Vol. 10. 2003. P.. 203-220
Synthesis of 3,4-diaryl-5-carboxy-4,5-dihydroisoxazole 2-oxides as valuable synthons for anticancer molecules
The convenient regioselective scalable synthesis of 3,4-diaryl-5-carboxy-4,5-dihydroisoxazole 2-oxides was developed based on a condensation of simple starting materials (arylbenzaldehydes, arylnitromethanes, and ethoxycarbonylmethylpyridinium bromide) under mild conditions. The obtained synthons can be applied for the synthesis of 3,4-diarylisoxazole derivatives capable of suppressing malignant growth. © 2017 Elsevier Ltd
Authors
Chernysheva N.B. 1 , Maksimenko A.S. 1 , Andreyanov F.A. 1 , Kislyi V.P. 1 , Strelenko Y.A. 1 , Khrustalev V.N. 2, 3 , Semenova M.N. 4 , Semenov V.V. 1
Journal
Issue number
48
Language
English
Pages
6728-6735
State
Published
Link
Volume
73
Year
2017
Organizations
- 1 N. D. Zelinsky Institute of Organic Chemistry, RAS, 47 Leninsky Prospect, Moscow, 119991, Russian Federation
- 2 Faculty of Science, RUDN University, 6 Miklukho-Maklay Street, Moscow, 117198, Russian Federation
- 3 A. N. Nesmeyanov Institute of Organoelement Compounds, RAS, 28 Vavilov Street, Moscow, 119991, Russian Federation
- 4 N. K. Koltzov Institute of Developmental Biology, RAS, 26 Vavilov Street, Moscow, 119334, Russian Federation
Keywords
3,4-Diarylisoxazoles; 3,4-Diarylisoxazoline oxides; Anticancer synthons; Carbonylmethylpyridinium
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IOP Conference Series: Materials Science and Engineering. Vol. 262. 2017.