Suppression of growth and metastasizing of T-Cell lymphoma in mice infected with American trypanosomiasis at different stages of experimental infection

Antitumor activity of Trypanosoma cruzi CH4 strain isolated in Mexico was studied. This parasite is not tumoritropic, but inhibits the growth and metastasizing of solid L5178Y-R lymphoma transplanted to Balb/C mice. Conditioned medium from cell cultures infected with this strain produced a cytostatic effect. Possible mechanisms of this phenomenon are discussed. © 2004 Plenum Publishing Corporation.

Authors
Mel'nikov V.G. 2 , Fierro Velasko F.H. , Dobrovinskaya O.R. 1
Journal
Бюллетень экспериментальной биологии и медицины\r\nКлеточные технологии в биологии и медицине (Bulletin of Experimental Biology and Medicine)
Publisher
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Issue number
5
Language
English
Pages
475-478
State
Published
Link
External link
DOI
10.1023/B:BEBM.0000038157.69208.27
Volume
137
Year
2004
Organizations
  • 1 Department of Microbiology, Russian Univ. of Peoples' Friendship, Moscow, Russian Federation
  • 2 Center for Biomedical Studies, Medical Faculty, University of Colima, Mexico
Keywords
Antitumor activity; L5178Y-R lymphoma; Trypanosoma cruzi
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