The use of a titanium-containing drug for the prevention of severe degrees of radiation mucositis in patients with metal structures in the oral cavity [Применение титаносодержащего препарата для профилактики тяжелых степеней лучевого мукозита у пациентов с металлоконструкциями в полости рта]

Introduction. Oral mucositis is one of the earliest and most frequent complications of radiation therapy or chemotherapy in patients diagnosed with oropharyngeal cancer. Because of this pathology, therapeutic interventions are most often used, thereby poor treatment is considered an etiological factor of oral mucositis. Now, this issue is being actively studied in the world, but a unified algorithm for treatment and prevention of oral mucositis has not been formed. The study objective – is to evaluate the effect of titanium glycerosolvate aquacomplex in reducing the intensity of radiation induced reactions and reducing the frequency of interruptions. Materials and methods. 52 patients diagnosed with oropharyngeal cancer were included in this study, treated with radiotherapy or chemotherapy. for prophylaxis of severe stages of oral mucositis, 32 patients underwent standard symptomatic therapy (group 1, control group); 20 patients took titanium glycerosolvate aquacomplex in accordance with symptomatic therapy (group 2). Results. In the group 1 only 61.7 % of patients completed treatment. In the group 280 % of patients completely underwent antitumor therapy. At the same time, they developed oral mucositis of the I–II degree. Also, in the group of the studied drug, in 100 % of cases, therapy was performed without interruptions. Conclusion. using titanium glycerosolvate aquacomplex for the prophylaxis of severe stages of oral mucositis during radiotherapy or chemotherapy of oropharyngeal cancer is effective and safe. It is also convenient from the medical and economic side, thanks to the ability to use it on an outpatient basis. © 2022 National University of Science and Technology MISIS. All rights reserved.

Sekretnaya A.O. 1 , Zaderenko I.A. 1, 2 , Ivanov S.Yu. 1, 3 , Alieva S.B.2 , Dymnikov A.B. 1 , Kaledin R.R.2 , Hachem H.A. 1
Номер выпуска
  • 1 Peoples’ Friendship University of Russia, 6 Miklukho-Maklaya St., Moscow, 117198, Russian Federation
  • 2 N.N. Blokhin National Medical Research Center of Onсology, Ministry of Health of Russia, 24 Kashirskoe Shosse, Moscow, 115478, Russian Federation
  • 3 I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Bld. 2, 8 Trubetskaya St., Moscow, 119991, Russian Federation
Ключевые слова
Metal structures; Oral mucositis; Titanium glycerosolvate aquacomplex
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