Regional population patterns of congenital epidermolysis bullosa and prevention approaches

The prevalence of epidermolysis bullosa (EB) and the proportion of different types vary significantly in populations of various countries and con-stituent units of the Russian Federation, which determines approaches to follow-up, prevention, and symptomatic therapy. Objective. To perform an epidemiological analysis of EB in Dagestan and determine ways to its prevention and follow-up. Material and methods. Between 2019 and 2021, patients with confirmed and suspected EB were examined. Results and conclusion. By 2021, 130 BE patients were registered. Of these, 64% were diagnosed with simple type, 6% with borderline type, 28% with dystrophic type and 1% with Kindler syndrome. In the Republic of Dagestan, the percentages of patients with recessively and domi-nantly inherited mutations are approximately the same. In patients with dominant type, a thorough clinical examination is necessary, and in patients with recessive type, a detailed family history should be taken. Patients with a family history of EB or those included in the risk group should be closely monitored by a pediatrician and dermatologist until the age of 6—7 years. Considering that Dagestan is a southern region and the climate there is hot, a bunch of preventive measures during the summer is required. It is necessary to provide patients with EB to stay in a room with artificially cooled air, create a safe environment, reduce (exclude) physical activity, household chores. © 2022, Media Sphera Publishing Group. All rights reserved.