One of the leading trends in modern medicine is the principle of prevention, which consists in preventing the formation of diseases and complications of therapy. The main damaging factor during respiratory support in patients with inhomogeneous lung tissue injury is tidal volume (TV). With traditional pressure controlled mechanical ventilation (PCMV), controlling the TV delivered to the child is difficult due to the variable mechanical properties of the lung tissue. PCMV algorithms with targeted TV, used in neonatology and in young children, make it possible to adjust the parameters of endotracheal respiratory support automatically. Thus, the principle of prevention is observed from inspiration to inspiration, and TV values become more constant, despite the changing respiratory mechanics. This protects the lungs from volumotrauma and ensures favorable outcomes. The purpose of this work is to review the existing recommendations on the use of dual-control modes of ventilation in newborns and young children and to present a protocol for preparing the breathing apparatus and controlling parameters when using PCMV with guaranteed TV. © 2022, Pediatria Ltd. All rights reserved.