Urinary tract infections in patients with type 2 diabetes mellitus with pharmacological glucosuria

Selective inhibitors of sodium-glucose cotransporter belong to a new class of drugs for the treatment of type 2 diabetes mellitus. The mechanism of their action is based on insulin-independent reduction of glucose reabsorption in the proximal renal tubules, which leads to stimulation of its excretion in the urine and, accordingly, to a decrease in the concentration of glucose in the blood plasma. Drugs of this group demonstrate effectiveness in the treatment of type 2 diabetes, but their use may be associated with an increased frequency of urinary tract infections. Pharmacological glucosuria, which leads to a decrease in the concentration of glucose in the blood, creates the preconditions for the occurrence of urinary tract infections. Urinary tract and genital infections are the most common adverse events associated with the use of sodium-glucose cotransporter inhibitors. In the presented literature review for 2016-2019, the relationship between urinary tract infections in patients with type 2 diabetes mellitus and therapy with sodium-glucose cotransporter inhibitors was analyzed. © 2020 Consilium Medikum. All rights reserved.

Авторы
Sturov N.V. 1 , Popov S.V. 1, 2 , Mamporia N.K.2 , Mager A.A. 1
Номер выпуска
11
Язык
Русский
Страницы
106-109
Статус
Опубликовано
Том
92
Год
2020
Организации
  • 1 People’s Friendship University of Russia, Moscow, Russian Federation
  • 2 Central Clinical Hospital of St. Alexy of the Moscow Patriarchate, Moscow, Russian Federation
Ключевые слова
Type 2 diabetes mellitus; Type 2 sodium-glucose cotransporter inhibitors; Urinary tract infections
Дата создания
20.04.2021
Дата изменения
20.04.2021
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/72778/
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