Antibacterial therapy of severe community-acquired pneumonia in adults-Is there a need for new drugs?

Community-acquired pneumonia (CAP) is one of the most frequent acute infectious diseases in developed countries. Particular attention should be given to severe CAP, characterized by high mortality, high frequency of ineffectiveness of Initial antibiotic therapy and treatment costs. The spread of pneumococcal isolates with reduced susceptibility to penicillin, III generation cephalosporins, macrolides, the risk of increasing the incidence of diseases caused by methicillin-resistant staphylococci and Enterobacteriaceae producing extended spectrum beta-lactamases (ESBL), led to a significant increase In interest in new antimicrobials (AMM) in CAP therapy. The review presents current data on the epidemiology and etiology of severe CAP (including trends in the antibiotic resistance of the main bacterial pathogens in the Russian Federation), outlines the bask principles of antibiotic therapy. The features of the activity spectrum, pharmacological characteristics, the results of clinical studies of the most promising antimicrobials-ceftaroline, solithromycin, new quinolones (dalafloxacin, nonmonoxacin, etc.), and omadacycline, are considered. © 2019 Media Sphera Publishing Group. All rights reserved.

Авторы
Rachina S.A. 1 , Zakharenkov J.A.2 , Yatsyshina S.B.3 , Bobyiev A.A.2, 4 , Khruleva Yu.V. 1
Номер выпуска
3-4
Язык
Русский
Страницы
38-47
Статус
Опубликовано
Том
64
Год
2019
Организации
  • 1 RUDN University, Moscow, Russian Federation
  • 2 Interregional Association for Clinical Microbiology Ond Antimicrobial Chemotherapy, Smolensk, Russian Federation
  • 3 Ctrl. Res. Inst. Ol Epidemiol. of Fed. Serv. on Customers' Rights Protect. and Hum. Well-being Survlnc., Moscow, Russian Federation
  • 4 Smolensk State Medical University of Ministry of Heolth of Russian Federation, Smolensk, Russian Federation
Ключевые слова
Antibacterial therapy; Drug combinations; New antimicrobial drugs; Severe community-acquired pneumonia
Дата создания
24.12.2019
Дата изменения
24.12.2019
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/55482/