Preclinical trials of L-lysine-α-oxidase, an antitumor enzyme

The effect of L-lysine-α-oxidase from a representative of the Trichoderma genus on the humoral immune response to protein antigens was studied. It was shown that repeated fife-fold intravenous administrations of L-Iysine-α-oxidase in a dose of 35 U/kg had no depressive action on the humoral immunity. The enzyme had no suppressive effect on the delayed type hypersensitivity to xenogenous erythrocytes. The use of L-lysine-α-oxidase in a therapeutic dose or in a twice as higher dose had no reliable effect on the leukocyte migration capacity vs. the control.

Номер выпуска
9-10
Язык
Русский
Страницы
33-36
Статус
Опубликовано
Том
55
Год
2010
Организации
  • 1 N. F. Gamaleya Research Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences, Moscow, Russian Federation
  • 2 Russian Peoples' Friendship University, Moscow, Russian Federation
Ключевые слова
Immunogenic properties; L-lysine-α-oxidase; Trichoderma
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/2675/