The effect of ETA receptor blockade on cardiomyocyte apoptosis and myocardial hypertrophy development in genetically hypertensive rats

Cardiomyocyte apoptosis and hypertrophy have been studied in the left and right ventricular myocardium of spontaneously hypertensive rats without treatment and after 10-day administration of the ETA-receptor antagonist BQ-123. It is established that BQ-123 prevents the activation of cardiomyocyte apoptosis and significantly decreases the extent of hypertrophy development in the left ventricular myocardium, but does not influence the same mechanisms in the right ventricular myocardium.

Авторы
Редакторы
-
Издательство
-
Номер выпуска
12
Язык
Русский
Страницы
22-24
Статус
Опубликовано
Подразделение
-
DOI
-
Номер
-
Том
75
Год
2012
Организации
  • 1 Department of Medicine, Russian University of Peoples Friendship, ul. Miklukho-Maklaya 6, Moscow, 117198, Russian Federation
Ключевые слова
Apoptosis; BQ-123, ETA receptor; Cardiomyocytes; Endothelin-1; Hypertension
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/2203/