Lupus nephritis and thrombotic microangiopathy: A review; [Волчаночный нефрит и тромботическая микроангиопатия]

Lupus nephritis (LN) is one of the most common organ-specific manifestations of systemic lupus erythematosus (SLE). Various clinical signs of LN develop in at least 50% of patients with SLE. In addition to LN, the spectrum of renal lesions associated with SLE also includes vascular pathology. One of the variants of renal microvascular injury is thrombotic microangiopathy (TMA), the mechanisms of which are diverse. The review focuses on the main forms of TMA, including antiphospholipid syndrome and nephropathy associated with antiphospholipid syndrome, TMA caused by complement system regulation disorders and deficiency of ADAMTS13. In most cases, these forms of TMA are combined with LN. However, they may also exist as a single form of kidney damage. This article discusses the TMA pathogenesis, the impact on kidney prognosis, and treatment options. © 2024 Consilium MediCum. All rights reserved.

Авторы
Bobrova L.A. , Kozlovskaya N.L.
Номер выпуска
6
Язык
Русский
Страницы
628-634
Статус
Опубликовано
Том
96
Год
2024
Организации
  • 1 Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
  • 2 Patrice Lumumba People’s Friendship University of Russia, Moscow, Russian Federation
  • 3 Yeramishantsev City Clinical Hospital, Moscow, Russian Federation
Ключевые слова
lupus nephritis; thrombotic microangiopathy
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