High levels of cytokines IL-17A, IL-18, VEGF-A are biomarkers of the incompleteness of the immune inflammatory process, signaling the danger of developing postcovid syndrome in the period of COVID-19 reconvalescence

The development of post-ovoid syndrome is the serious consequence of COVID-19. The link of the clinical manifestations of COVID-19 with the cytokine profile remains insufficiently investigated until now. Objective. To study the biomarkers of the incompleteness of the immune hyperinflammatory process in the period of reconva-lescence of patients with COVID-19 in order to predict the threat of post-covid syndrome based on the study of the dynamics of changes in serum cytokine levels IL-1b, TNF-α, IL-4, IL-6, IL-8, IL-10, IL-17A, IL-18, VEGF-A and interferons IFN-α, IFN-γ. Patients and methods. IL-1b-4,-6,-8,-10,-17A,-18 cytokines, TNF-α,VEGF-A, IFN-α, IFN-γ have been studied in dynamics,(enzyme immunoassay) in patients with moderate COVID-19 (n = 45, 61 (57; 71) years) in the acute period (study group (SG) 1a), against the background of antiviral therapy (GI1b) and upon discharge from the hospital (SG1b). Comparison group (CG) – 50 conditionally healthy people. Results. It was found that the levels of IL-1β, TNF-α, IL-8 were normalized in GI1b, in 35% of cases IL-6, while the level of cytokines IL-18, IL-17A, VEGF-A remained at the values determined in the acute course of COVID-19 (p > 0.05). Conclusion. Elevated levels of IL-17A, IL-18, VEGF-A in the period of COVID-19 reconvalescence could be prognostic biomarkers indicating the continuing incompleteness of the immune inflammatory process, which determines the need for cytokine monitoring in the post-ovoid period and requires the creation of targeted immunotherapy strategies. © 2023, Dynasty Publishing House. All rights reserved.