Clinical case of Mediterranean fever (periodic fever) and granulomatous inflammation related to tattooing

The range of diseases and conditions arising and/or triggered by tattooing is constantly expanding. We present a clinical case of granuloma-tous inflammation in the tattoo area and triggering of Mediterranean fever exacerbation (periodic fever) by tattooing. Objective. To describe a case of Mediterranean fever (periodic fever) and granulomatous inflammation related to tattooing Material and methods. Patient M., 30 years old, presented with complaints of abnormal tattoo appearance, burning and swelling in the area of black pigment insertion, as well as with signs and symptoms of familial Mediterranean fever after tattooing. Histological examination of the granulomatous inflammation site was performed. Results. Retrospectively, an exacerbation of familial Mediterranean fever related to tattooing was diagnosed. The examined sample of tattooed skin revealed granulomatous inflammation around a foreign body (black pigment). Despite complete epithelialization, fibrosis of all skin lay-ers with histoarchitecture alteration and redistribution of microcirculatory blood vessels was observed. Conclusion. The presented clinical case is an example of post-tattoo complications with systemic manifestation (exacerbation of familial Mediterranean fever) and a local complication of granulomatous inflammation around the foreign body (pigment). © 2022, Media Sphera Publishing Group. All rights reserved.