Pentamethine cyanine dyes with alkynyl group as perspective structure for conjugation with targeting moiety

We report a modified carbocyanine-based asymmetric fluorescent dye, suitable for the azide-alkyne cycloaddition reaction, that possesses promising photochemical properties (Φfl = 0,49). As an example of usage of the new fluorophore, it was conjugated to a ligand targeting prostate-specific membrane antigen (PSMA), one of the widely utilized prostate cancer markers. © 2024 Elsevier Ltd

Авторы
Uspenskaia A.A. , Doroshenko I.A. , Popovicheva K.A. , Shmychkov N.V. , Pryakhina E.V. , Shafikov R.R. , Skvortsov D.A. , Beklemishev M.K. , Zaborova O.V. , Podrugina T.A. , Machulkin A.E. , Beloglazkina E.K.
Журнал
Bioorganic and Medicinal Chemistry Letters
Издательство
Elsevier Ltd
Язык
Английский
Статус
Опубликовано
Ссылка
Внешняя ссылка
DOI
10.1016/J.BMCL.2024.130025
Номер
130025
Том
115
Год
2025
Организации
  • 1 Lomonosov Moscow State University, Chemistry Dept., Leninskie Gory, Building 1/3, GSP-1, Moscow, 119991, Russian Federation
  • 2 Lomonosov Moscow State University, Fundamental Physical and Chemical Engineering Dept., Leninskie Gory, Building 1/3, GSP-1, Moscow, 119991, Russian Federation
  • 3 National Research University Higher School of Economics, Biology and Biotechnology Dept., Profsoyuznaya St., 33/4, Moscow, 117418, Russian Federation
  • 4 Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences, GSP-7, Ulitsa Miklukho-Maklaya, 16/10, Moscow, 117997, Russian Federation
  • 5 Department for Biochemistry, People's Friendship University of Russia Named after Patrice Lumumba (RUDN University), Moscow, 117198, Russian Federation
Ключевые слова
Asymmetric carbocyanine; Click reaction; Cyanine dyes; Photochemistry
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