Prevalence and genetic diversity of group a rotavirus genotypes in moscow (2019–2020)

Group A rotavirus (RVA) infection is the leading cause of hospitalization of children under 5 years old, presenting with symptoms of acute gastroenteritis. The aim of our study was to explore the genetic diversity of RVA among patients admitted to Moscow Infectious Disease Clinical Hospital No. 1 with symptoms of acute gastroenteritis. A total of 653 samples were collected from May 2019 through March 2020. Out of them, 135 (20.67%) fecal samples were found to be positive for rotavirus antigen by ELISA. RT-PCR detected rotavirus RNA in 80 samples. Seven G-genotypes (G1, G2, G3, G4, G8, G9, and G12) and three P-genotypes (P[8], P[4], and P[6]) formed 9 different combinations. The most common combination was G9P[8]. However, for the first time in Moscow, the combination G3P[8] took second place. Moreover, all detected viruses of this combination belonged to Equine-like G3P[8] viruses that had never been detected in Russia before. The genotype G8P[8] and G9P[4] rotaviruses were also detected in Moscow for the first time. Among the studied rotaviruses, there were equal proportions of Wa and DS-1-like strains; previous studies showed that Wa-like strains accounted for the largest proportion of rotaviruses in Russia. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Авторы
Yuzhakov A.1, 2 , Yuzhakova K.1 , Kulikova N.1 , Kisteneva L.1 , Cherepushkin S.1 , Smetanina S.3 , Bazarova M.3 , Syroeshkin A. 4 , Grebennikova T.1
Журнал
Издательство
MDPI AG
Номер выпуска
6
Язык
Английский
Статус
Опубликовано
Номер
674
Том
10
Год
2021
Организации
  • 1 Laboratory of Molecular Diagnostics, N. F. Gamaleya Federal Research Center for Epidemiology & Microbiology, Moscow, 123098, Russian Federation
  • 2 Laboratory of Biochemistry and Molecular Biology, Federal State Budget Scientific Institution “Federal Scientific Center VIEV”, Moscow, 109428, Russian Federation
  • 3 Moscow Clinical Hospital No. 1 of Infectious Diseases, Moscow, 125310, Russian Federation
  • 4 Department of Pharmaceutical and Toxicological Chemistry, Peoples’ Friendship University of Russia (RUDN University), Moscow, 117198, Russian Federation
Ключевые слова
Acute gastroenteritis; DS-1-like; Genotype; Rotavirus A; Wa-like
Дата создания
20.07.2021
Дата изменения
20.07.2021
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/74246/
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