A quail is a bird of the order of Galliformes, which areconsidered rather primitive birds, and most of the species in this order are medium-sized birds. Their body form and behavioral characteristics are similar to those of domestic chickens. The aim: Histological study of loop of Henle in male and female quail birds. Material and Methods: A total of thirty-six adult male and female Japanese quail were allocated randomly into four different age groups of 30, 90, 180, and 270 days. Data analysis was performed using SPSS-22. The results the outer diameter of the thin tubule in the loop of Henle in females increased by 4% compared to males. A 12%increase was noted in the outer diameter of the thickened tubule and the collecting tubes in male quail compared to the females at 30 days of age.