Moonlight functions of glycolytic enzymes in cancer

Since an extensive genome research has started, basic principle “one gene—one protein—one function” was significantly revised. Many proteins with more than one function were identified and characterized as “moonlighting” proteins, which activity depend not only on structural peculiarities but also on compartmentation and metabolic environment. It turned out that “housekeeping” glycolytic enzymes show important moonlight functions such as control of development, proliferation, apoptosis, migration, regulation of transcription and cell signaling. Glycolytic enzymes emerged very early in evolution and because of the limited content of genomes, they could be used as ancient regulators for intercellular and intracellular communication. The multifunctionality of the constitutively expressed enzymes began to serve cancer cell survival and growth. In the present review we discuss some moonlight functions of glycolytic enzymes that important for malignant transformation and tumor growth.

Authors
Shegay Petr V.1 , Shatova Olga P. 2, 3 , Zabolotneva Anastasia A.2, 4 , Shestopalov Aleksandr V.2, 4, 5 , Kaprin Andrei D. 1, 3
Publisher
Frontiers Media S.A.
Language
English
Pages
1076138
Status
Published
Volume
10
Year
2023
Organizations
  • 1 Federal State Budget Institution, National Medical Research Radiology Center of the Ministry of Healthcare of the Russian Federation, Moscow, Russia
  • 2 Department of Biochemistry and Molecular Biology, Faculty of Medicine, Pirogov Russian National Research Medical University, Moscow, Russia
  • 3 Biochemistry Department, Peoples' Friendship University of Russia, Moscow, Russia
  • 4 National Medical Research Centre for Endocrinology, Laboratory of Biochemistry of Signaling Pathways, Moscow, Russia
  • 5 Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of the Russian Federation, Moscow, Russia
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