Antibiotic resistance of moraxella catarrhalis strains isolated from patients with complicated acute respiratory viral infections and other acute respiratory diseases

In recent years, acute respiratory viral infections (ARVIs) and other acute respiratory diseases (ARDs) have acquired some new characteristics of the disease course. The structure of complications has changed, in particular, such complications as community-acquired pneumonia (CAP) and lesions to the upper respiratory tract have become significantly more common. CAP remains one of the main causes of death in patients with ARVIs and other acute respiratory infections due to bacterial resistance to antibiotics. Objective. To assess drug sensitivity of Moraxella catarrhalis strains isolated from patients with complicated ARVIs or ARDs. Materials and methods. Drug susceptibility assessment was performed using the disk diffusion method (DDM) and gradient diffusion method (E-test). The production of β-lactamases was evaluated using nitrocephine, a chromogenic substrate. Results. Isolated strains of M. catarrhalis were resistant to third-generation cephalosporins and sensitive to fourth-and fifth-generation cephalosporins. More than 70% of M. catarrhalis strains developed resistance to macrolides; 8% of strains were resistant to amoxiclav. All isolated M. catarrhalis strains were sensitive to respiratory fluoroquinolones, carbapenems, and ampicillin-sulbactam. © 2021, Dynasty Publishing House. All rights reserved.

Authors
Kraeva L.A.1, 2 , Burgasova O.A. 3, 4 , Petrova I.S.5 , Samoylova A.A. 1 , Rogacheva E.V.1 , Taranova M.V.6 , Bespalova G.I. 7
Publisher
Dynasty Publishing House
Number of issue
3
Language
Russian
Pages
85-91
Status
Published
Volume
19
Year
2021
Organizations
  • 1 Saint Petersburg Pasteur Research Institute of Epidemiology and Microbiology, Saint Petersburg, Russian Federation
  • 2 S.M.Kirov Military Medical Academy, Saint Petersburg, Russian Federation
  • 3 Peoples' Friendship University of Russia (RUDN), Moscow, Russian Federation
  • 4 N.F.Gamaleya National Research Center for Epidemiology and Microbiology, Moscow, Russian Federation
  • 5 Clinical Hospital for Infectious Diseases No 2, Moscow, Russian Federation
  • 6 I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
  • 7 I.I.Mechnikov North-Western State Medical University, Saint Petersburg, Russian Federation
Keywords
Bacterial sensitivity to antibiotics; Complications of acute viral infections; Moraxella catarrhalis
Date of creation
06.07.2022
Date of change
06.07.2022
Short link
https://repository.rudn.ru/en/records/article/record/84774/
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