Effects of Pharmacy Care Program on medication adherence in outpatients with stable coronary artery disease: a randomized controlled study [Рандомизированное контролируемое исследование влияния программы “Фармацевтическая опека” на приверженность фармакотерапии амбулаторных больных стабильной ишемической болезнью сердца]

Aim. To assess the effects of the Pharmacy Care Program on medication adherence in outpatients with stable coronary artery disease (SCAD). Material and methods. An open randomized controlled study was conducted in primary care clinic over the period of 20192020. All subjects (n=126) were randomized at visit 1 into the multifaceted intervention group (n=63) or control group (n=63) and invited 12 months after to visit 2. Patients of intervention group were included into the Pharmacy Care Program, which consisted of the following components: pharmacistled counseling, provision of education materials and 7day pillbox, weekly SMSreminders. Medication adherence was measured initially and at the end of the study period by means of eightitem Morisky Medication Adherence Scale (MMAS8) and SelfEfficacy for Appropriate Medication Use Scale (SEAMS). Results. The implementation of the Pharmacy Care Program improved medication adherence in SCAD outpatients with MMAS8 median score of 7,08,0 (p<0,001) and SEAMS median score of 35,036,0 (p=0,017). In the control group, no changes (p=0,123) in MMAS8 score were revealed, while SEAMS score decreased from 35,0 down to 34,5 (p=0,003). The reduction in systolic blood pressure (p=0,049) and risk of urgent hospital admission (OR=0,28; 95% CI, 0,080,99; p=0,041) was registered in the intervention group in contrast to the control group over the 12month period. Conclusion. The multicomponent intervention within the Pharmacy Care Program contributed to an increase in the adherence to pharmacotherapy of outpatients with stable CAD. © 2022 Vserossiiskoe Obshchestvo Kardiologov. All rights reserved.