This article is devoted to the development of methods for calculating heat and humidity regime in the building envelope. The equation of steady-state thermal conductivity with boundary conditions of the third kind and the formula for calculating heat losses of a building based on the heat transfer equation have been considered. The equation of unsteady-state thermal conductivity as well as its solution using the discrete-continual approach has also been studied. The solution of the unsteady-state heat conductivity problem with invariable over time boundary conditions using the discrete-continuous approach was proposed by A.B. Zolotov and P.A. Akimov. The subsequent modernization of the solution was conducted by V.N. Sidorov and S.M. Matskevich. The unsteady-state equation of moisture transfer based on Fick's second law using the theory of moisture potential is derived. The solution of the unsteady-state moisture transfer equation using the finite difference method according to an explicit difference scheme as well as the solution of the unsteady-state moisture transfer equation using the discrete-continuous approach is demonstrated. To prove the effectiveness of using the discrete-continuous approach in the area of the unsteady-state humidity conditions we compared the calculation results of the distribution of moisture in a single-layer enclosing structure made of aerated concrete using two methods of moisture potential theory. It was found that the difference in the results of calculation by the discrete-continual formula and by the method of finite differences does not exceed 3.2%. © 2021 Institute of Physics Publishing. All rights reserved.