Morphological substantiation of laparoscopic suturing of stomach ulcer with formation of a covered perforation

Objective. Morphological substantiation of laparoscopic suturing of gastric ulcer with formation of a covered perforation. Material and methods. To analyze morphological tissue reaction in surgical area, we used 12 Chinchilla rabbits. All animals were divided into 2 groups by 6 animals. The main group enrolled rabbits undergoing suturing of perforated gastric ulcer with formation of a covered perforation by anterior stomach wall. In the control group, gastric perforation was sutured by conventional double-row suture. For histological analysis, 2 animals in each group were withdrawn from the experiment after 7, 14 and 21 days. We excised gastric wall within the area of perforation closure. Morphological data on healing process were compared between both groups. Results. Stomach deformation after 7 days was more severe in the main group compared to simple suturing. However, these dif- ferences were absent after 21 days. Morphological analysis revealed postoperative transmural necrosis after 7 days. Signs of early epithelialization were more obvious in the main group. After 21 postoperative days, we observed almost completely restored dif- ferentiation of stomach wall layers in both groups of animals. © 2022, Media Sphera Publishing Group. All rights reserved.