he variety of professional and ethical features of clinicians’ activities requires improving the capabilities of monitoring technologies. This paper reviews the regional experience of the formation of the quality and safety management system of medical care (based on the 10-year-period materials of the Tyumen region). The key area of this study is to analyze the development of trends and features of regional experience in the formation of a quality and safety management system for medical care, the formation of technologies, and to develop insurance mechanisms for professional liability of medical workers and insurance risks (historical perspective based on the materials of the Tyumen region, Russian Federation). A regional, departmental medical care quality control technology has been created to reduce morbidity, mortality and prevent patient health risks. A technological base for the management of medical care has been formed as a factor in reducing morbidity and as the basis for the formation of a system for reducing health risks, which includes issues of continuous, systematic training of medical personnel, indicators of medical care quality, the level of quality of forensic examinations. To improve the efficiency of departmental control of medical care quality, during the study a medical care and clinical and expert work control department was established in the Department of Health of the Tyumen Region (DH TR). The key link in the departmental control of the medical care quality is the “expert commissions” of medical institutions (MI), the key link in the interdepartmental control of the medical care quality is the “health, social and medical insurance services”. The studies were initiated during the transition to single-channel funding and assessments of medical institutions on a completed case basis. © 2022, Venezuelan Society of Pharmacology and Clinical and Therapeutic Pharmacology. All rights reserved.