Most studies agree on FDI to be a driver of the economic growth in developing countries and, unlike other forms of capital flows; they form stable long-term connections in the world economy. Therefore, the specifics and trends of FDI in ASEAN are studied in this paper, focusing on the key determinants of FDI flows to ASEAN countries that form the investment climate of the region. Along with traditional determinants of FDI within location advantages of Dunning’s eclectic paradigm the authors analyze macroeconomic (CPI, GDP per capita annual growth rate), institutional (the quality of institutions), social (human development) and regional determinants (the share of intraregional trade in total regional trade based on their market size) and their influence on investment attractiveness of ASEAN regional block. The paper uses panel data for the period 2008–2017. So the key figures for each determinant are characterized by whether it has a positive, negative or no influence on the flows of FDI in the region.