Rh(III)-Catalyzed C−H Activation/Annulation of Aryl Hydroxamates with CF3-Containing α-Propargyl α-Amino Acid Derivatives

A series of new orthogonally protected α-CF3-substituted α-amino carboxylates, and α-amino phosphonates decorated with pharmacophore isoquinolone core has been elaborated through the Rh(III)-catalyzed C−H activation/annulation of aryl hydroxamates with propargyl-containing α-amino acid derivatives and their phosphorus analogues.

Authors
Vorobyeva D.V.1 , Petropavlovskikh D.A.1 , Godovikov I.A.1 , Osipov S.N. 1, 3 , Nefedov S.E. 2
Number of issue
12
Language
English
Pages
1883-1890
Status
Published
Volume
2021
Year
2021
Organizations
  • 1 Institute of Organoelement compounds|Russian Academy of Sciences
  • 2 Peoples' Friendship University of Russia (RUDN University)
  • 3 Institute of General and Inorganic Chemistry|Russian Academy of Sciences
Keywords
Amino phosphonates; catalysis; C-H activation; Fluorinated amino acids; isoquinolones
Date of creation
16.12.2021
Date of change
16.12.2021
Short link
https://repository.rudn.ru/en/records/article/record/80388/
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