Effect of metformin on doxorubicin-induced cardiotoxicity in experiment

The article provides an overview of the currently known descriptions of the mechanisms and toxic effects of two drugs: doxorubicin, a first-line drug for the treatment of cancer, and the mechanisms of action of Metformin, a drug widely used for the treatment of diabetes mellitus 2. The review made with the usage of NCBI, PubMed and OxfordAcademic presents the analysis of published data on the protective effect of Metformin in its combined use with doxorubicin in an experiment in an attempt to reduce the manifestations of doxorubicin-induced cardiotoxicity. © 2021 Izdatel'stvo Meditsina. All rights reserved.

Authors
Ionov S.V. 1 , Orlova V.S. 1 , Kulbachevskaya N.Yu.2
Journal
Voprosy Onkologii
Publisher
Izdatel'stvo Meditsina
Number of issue
1
Language
Russian
Pages
35-39
Status
Published
Link
External link
DOI
10.37469/0507-3758-2021-67-1-35-39
Volume
67
Year
2021
Organizations
  • 1 Peoples' Friendship University of Russia, Moscow, Russian Federation
  • 2 N. N. Blokhin National Medical Research Center of Oncology, Moscow, Russian Federation
Keywords
Cardiotoxicity; Doxorubicin; Metformin; Oxidative stress; Reactive oxygen species
Date of creation
16.12.2021
Date of change
16.12.2021
Short link
https://repository.rudn.ru/en/records/article/record/77245/
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