Clinical experience with the use of topical isotretinoin in the treatment of papulopustular acne

The high prevalence of acne all over the world and in Russia, including its influence on the patients’ quality of life, the role of numerous en-vironmental factors, dietary habits and lifestyle on the disease determine the relevance of increasing the effectiveness of its treatment and the continuous search for affordable and convenient medicines safe in use. Objective. To demonstrate the high efficacy and safety of solution containing 0.025% isotretinoin in alcohol-glycol base in patients with pap-ulopustular acne. Material and methods. The study included 88 patients with papulopustular acne at the age from 18 to 47 years. In group 1 (n 48), patients were prescribed topically a drug containing 0.025% isotretinoin 1—2 times a day for 4—6 weeks. Patients of the 2nd group (n=40) received external therapy with a cream containing 0.1% adapalene up to 12 weeks according to medical direction to use. Results. After 12 weeks, the number of papules and pustules in patients of 1st group became less than in patients of 2d group (p<0.001), and a significant difference relative to the initial value was observed at each observation point (p<0.001) throughout the treatment. When as-sessing the global therapeutic effect (GTE), reliable positive results were obtained: already on the 30th day of treatment in the 1st group half of the patients noted a good efficacy of the drug — 2.1 points, and after 90 days, almost all rated the therapeutic efficacy at 2.9 points against 1.9 and 2.1 points in the 2nd group. © 2021, Media Sphera Publishing Group. All rights reserved.