In this paper the result of conducted numerical studies based on space calculation models are presented. It presents the results of a conducted numerical assessment of the influence of masonry infill walls on variation and redistribution of efforts arising in columns of a cast-in-situ framed building. The quantitative data of the influence of masonry infill walls on the redistribution of longitudinal forces in columns of a nine-story of a cast-in-situ framed building are given. It is also shown the particularity of the redistribution of efforts in columns depending on their location on the plan and on elevation of a cast-in-situ framed building with masonry infill walls when designing considering the wind load or the failure of masonry infill walls of the first-floor.