According to various sources, 15-20% of the world territories, are the zones of ecological disaster, about 50% of the population live in environmentally unfriendly regions. Licorice medicinal plant with the scientific name of Glycyrrhize globra is one of the medicinal plants used in cosmetics, food, health and pharmaceutical industries. The main aim of the study is to present the data on the correction of deviations concerning the adaptation system activity of 13-14-year-old adolescent bodies, exposed to chemical pollution of the environment by means of a phytoadaptogen based on licorice. According to the obtained data, they established the reduction of chemical, environmental pollution factor negative effect on the adolescent's body: normalization of rhythm, blood pressure, heart rate, maximum oxygen consumption, and the adaptive potential of the circulatory system.The results of the study demonstrate that the use of Glycyrrhiza glabra root extract as an adaptogen can help the normalization of blood pressure, heart rate, and variation range among 14-year old adolescents living in conditions of environmental chemical pollution. Besides, it can be concluded that Glycyrrhiza glabra root extract is an positive natural adaptogen since it decreases the detrimental impact of chemical pollution factors on the adolescent body, and consequently results in relative normalization of blood pressure.