STRUCTURAL TRANSFORMATIONS OF PIRIFORM NEURONS IN DIFFERENT AREAS OF THE HUMAN CEREBELLAR CORTEX FROM BIRTH TO 6 YEARS

The article is devoted to the study of age-related changes in the size of piriform neurons (Purkinje cells) of the human cerebellum. Histological material has been obtained from 36 males aged from birth to 6 years who died as a result of injuries without brain damage. The material was grouped in annual intervals. Measurements of the area of piriform neurons were made in the posterior part of the anterior quadrangular lobule (H V), posterior quadrangular lobule (H VI) and paramedian lobule (H VII B). For this purpose, we used virtual images of sagittal paraffin sections of the cerebellar cortex 10 microns thick, stained with cresyl violet on Nissl. Average value, standard error and confidence interval were calculated for measurable indicators of different age groups. It has been established that in the course of postnatal ontogenesis an intensive increase in the size of piriform neurons is observed in the period from birth to 2-3 years, as well as in the anterior lobe of the cerebellum to 5 years, in the posterior lobe of cerebellum - mainly to 6 years. Left-hand asymmetry of mean group sizes of piriform neurons is observed in children aged from 1 to 5 years, including in the lateral zone H V - during the 1st and 2nd years of life, H VI - during the 1st and 5th years of life, H VII B - during the period from 2 to 4 years.